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羧基末端截短的 ( truncated)乙型肝炎病毒 ( HBV)表面抗原中蛋白 ( MHBst)能够反式激活多种病毒或细胞基因启动子的转录功能 ,与 HBV相关的肝细胞癌 ( hepatocellular carcinoma,HCC)发生密切相关。MHBst至少完全缺失蛋白 C-末端 S区的疏水区 ,才具有反式激活功能 ;S区的 N-末端疏水区 是反式激活所必须的 ,对应的编码基因 Pre S2 / S有效缺失位点在 2 2 1～ 573位核苷酸之间 ,这段核苷酸序列被称为“反式活性开启区”( trans- activity- on region,TAO)。MHBst的反式激活功能依赖于其 N-末端 Pre S2区的胞浆定位功能 ,激活的机制可能与 PKC依赖的信号转导途径有关。
The protein (MHBst) in the truncated hepatitis B virus (HBV) surface antigen transactivates the transcriptional function of various viral or cellular gene promoters, and the hepatocellular carcinoma (HCC) ) Is closely related. MHBst at least completely lack the hydrophobic region of the C-terminal S region of the protein to have transactivation function; the N-terminal hydrophobic region of S region is necessary for transactivation, and the corresponding pre-coding gene Pre S2 / S effective deletion site is at This nucleotide sequence is known as “trans-activity-on region” (TAO) between nucleotides 21-573. The transactivation function of MHBst depends on the cytoplasmic localization of its N-terminal Pre S2 region, which may be related to PKC-dependent signal transduction pathway.