维A酸时代前急性早幼粒细胞白血病的治疗急性早幼粒细胞白血病(APL)临床上表现为骨髓或外周血中异常的早幼粒细胞聚集,血纤蛋白原减少,易发生严重的出、凝血并发症,以致患者早期死亡。瑞典学者Hillestad在1957年报道了3例患者,病程表现极其凶险并具有严重的出血倾向,患者外周血中可见到大量早幼粒细胞。由于3例患者的生存期都只有数周,因此认为这是 Treatment of acute promyelocytic leukemia before the retinoid acid era Acute promyelocytic leukemia (APL) is clinically manifested as abnormal promyelocytic accumulation in the bone marrow or peripheral blood with reduced fibrinogen and severe exacerbation , Coagulation complications, resulting in early death of patients. In 1957, Hillestad, a Swedish scholar, reported 3 patients with extremely dangerous disease course and severe bleeding tendency. A large number of promyelocytic cells were seen in peripheral blood of patients. Because all 3 patients had a survival period of only a few weeks, they thought it was