Targeting相关论文
＜正＞纤维素作为一种生物可再生和生物相容性的绿色材料,近年来受到越来越多的关注,目前有大量工作对其进行物理和化学改性,以期得到......
Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expres
Pygopus-2 over-expression has been reported in several malignancies,such as ovarian,breast,lung and liver cancers.Here w......
Polymer-Assisted Synthesis and Functionalization of Fe_3O_4/Au Composite Nanoparticles for Precision
Development of functionalized Fe3O4/Au composite nanoparticles(NPs)having a controllable size,narrow size distribution,a......
MRI detection of endolymphatic hydrops in Meniere’s disease in 8 minutes using MIIRMR and a 20-chann
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目的探讨放射性同位素示踪技术在生物药临床研究中的应用价值。方法对3名健康志愿者静脉滴注131I标记的国际一类新药美珀珠单抗，通......
靶向给药系统(targeting drug delivery system,TDDS)能够选择性作用于病变部位,控制药物的分布与释放,提高药效和降低毒副作用,已......
线粒体不仅是细胞的能量单元,还是重要的活性氧产生场所。线粒体内的活性氧与正常的生理功能和人类疾病具有紧密的联系,包括细胞信......
The present paper describes the current urban poverty situation,examines the factors affecting the probability of a hous......
With the arrival of the era of global population aging,we strive for healthy aging and a healthy senior life rattier tha......
Ocular pathology serves as one vital branch subject of histopathology,and also as a basic ocular science analysing the p......
WITH increasing pressure for Chinese children to get into good high schools, home tutors have become very popular in man......
AIM:To develop a hepatocyte targeting pH-sensitiveliposome for drug delivery based on active targetingtechnology mediat......
AIM:To investigate the effects and mechanism of disruption of focal adhesion kinase(FAK) expression on collagen metaboli......
Voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability,and their abnormal ac......
With the support by the National Natural Science Foundation of China and National Science and Technology Major Project,t......
Can we treat neurodegenerative diseases by preventing an age-related decline in microRNA expression?
MicroRNA pathway is down-regulated in aged dopaminergic neurons:Parkinson’s disease(PD)is the most frequent motor neuro......
Traditional Chinese medicine,including herbal medicineand acupuncture,as one of the most important parts incomplementar......
The application of nanotechnology significantly benefits clinical practice in cancer diagnosis, treatment, and managemen......
MicroRNAs (miRNAs) play an important role in carcinogenesis in various solid cancers including breast can-cer. Down-regu......
Transporters are membrane proteins mediating permeation of organic and inorganic solutes through the plasma membrane and......
The interactions among drugs,tumor and host are critical for a response to therapy and for outcome.Anticancer herbs used......
Supramolecular medicinal chemistry field has been a quite rapidly developing,increasingly active and newly rising interd......
Objective:Despite platinum-based adjuvant chemotherapy has improved greatly patients’ outcomes,drug resistance poses a ......
目的 建立一种新型的靶向高效诱发肿瘤血管血栓栓塞体系磁流体-神经纤维网蛋白1抗体A6-链霉亲和素:生物素-短截型组织因子(MF-A6-S......
AIM: To explore the effects of siRNA silencing of PIK3CA on proliferation, migration and invasion of gastric cancer cell......
Appropriately controlled gene expression is fundamental for normal growth and survival of all living organisms.In eukary......
Gene therapy is one of the most attractive fields in tumor therapy. In past decades, significant progress has been achie......
MicroRNA-21(miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors.......
At a press conference on September 10, Beijing Centers for Disease Control and Prevention (CDC) announced that a new ro......
光动力治疗因其不良反应小、抗癌谱广等优势,越来越受到人们的重视。光动力治疗包含三要素:光敏剂、光和分子氧,缺一不可。酞菁类......
多西紫杉醇是第2代紫杉烷类广谱高效抗肿瘤药,目前已被FDA批准临床上用于卵巢癌、乳腺癌等的治疗。多西紫杉醇聚合物胶束因具粒径......
T cell mediated adoptive immune response has been characterized as the key to anti-tumor immunity. Scientists around the......
Preparation and Evaluation of Norcantharidin-encapsulated Liposomes Modified with a Novel CD19 Monoc
In this study,norcanthridin(NCTD)-encapsulated liposomes were modified with a novel murine anti-human CD19 monoclonal an......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
近年来,对于白血病治疗有一些研究进展,但白血病仍然是不能有效治愈.新观点认为这与存在药物抵抗的少量恶性细胞有关,这些细胞同时......
Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations
Epidermal growth fac tor receptor (EGFR) is one of the most commonly altered genes in human cancer by way of over-expres......
Although many anticancer therapies are used in clinic, few are tolerable for their side effects from killing of normal c......
目的 在大肠杆菌中表达并纯化BDNF-TAT融合蛋白,研究其靶向性及在脑中的分布.方法 重组质粒PET-30(a)-BDNF-TAT转染至大肠杆菌BL21......
hematological malignant tumors with CD19 high expression....
Adeno-associated virus(AAV)has rapidly become a promising gene delivery vector for its excellent advantages of low patho......
Preparation and Targeting Evaluation of Recombined Intrakine Plasmid pEGFP/SDF-1/KDE/Folate-Liposome
Objective: To prepare folate liposome complexes of recombinant plasmid pEGFP/SDF-1/KDEL with contained intrakine SDF-1/K......
A lipoplex (i.e., pDNA#1/lipid complex and transfection reagent for pDNA delivery) containing galactosylceramide (GalCer......
高分子药物递送载体材料具有良好的生物相容性和生物可降解性,可以有选择性的释放药物,以提高药物利用率和降低药物的副作用,因此,......
食品安全关系每个人的身体健康,随着国家的整治力度逐年加大,市面上流通的大部分食品已经能够符合食品安全标准。但这并不代表食品......
在近5年间,抗癌药的销售额达到了一个惊人的数字。在众多的抗肿瘤抗生素中,能够进入临床Ⅱ期的很少,获批上市的更少。本文对已上市......
目的探讨多肽介导的肿瘤靶向纳米粒载体的制备方法,并评价该载体的特性。方法合成多肽载体,用磁共振鉴定载体结构,用超声乳化法制......
目的:通过动物实验,研究提出植入靶向持续组织间化疗的概念的可行性,并与其他疗法比较此种疗法有何优越性.方法:用生物相容性和可......
