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１９８０～１９９１年在安徽、江苏和陕西省野鼠型ＥＨＦ疫区，对野鼠型ＥＨＦ的主要传染源进行了现场调查和实验研究，认为黑线姬鼠是野鼠型ＥＨＦ的主要宿主动物和传染源，这是因为：①黑线姬鼠是野鼠型ＥＨＦ疫区的优势鼠种（占当地鼠总数的６７．７３～９８．０４％），野外鼠密度高（２１．１６～３８．１２％）或较高（８．１８～１４．５２％）；②黑线姬鼠的季节消长与当地人群ＥＨＦ的发病率相一致；③黑线姬鼠携带ＥＨＦＶ抗原的阳性率高；从ＥＨＦＶ抗原阳性的鼠肺中能分离到ＥＨＦＶ：④ＥＨＦＶ抗原阳性黑线姬鼠的血、尿和粪具有传染性：⑤现场调查证明，ＥＨＦＶ在黑线姬鼠间可通过革螨、恙螨叮刺传播。根据流行病学调查资料，拟定了以灭鼠为主的预防措施；并提出野鼠型ＥＨＦ疫源地控制的五项检测指标，即：①鼠密度控制在１．０％以下；②鼠ＥＨＦＶ抗原阳性率在３．０％或５．０％以下；③鼠ＥＨＦＶ抗体阳性率在５．０％或１０．０％以下；④本地常住健康人群ＥＨＦＶ抗体阳性率应为零；⑤ＥＨＦ发病是个别的或没有病人。几年来的调查结果进一步证明。对野鼠型ＥＨＦ疫区所采取的五项控制方法和指标有效可行，即灭鼠是预防ＥＨＦ的关键，大面积药物反复灭鼠是控制野鼠型ＥＨＦ疫源地?
From 1980 to 1991, field investigation and experimental study on the main source of EHF in wild mice in Anhui Province, Jiangsu Province and Shaanxi Province were conducted. It is concluded that Apodemus agrarius is the main host animal and source of infection of EHF. This is because: (1) Apodemus agrarius is dominant species of rodent EHF (67.73-98.04% of the total number of local mice), wild deer (21.16-38.12%) or (8.18-14.52%). The seasonal fluctuation of Apodemus agrarius was consistent with the incidence of EHF in the local population. The positive rate of EHFV antigen was higher in Apodemus agrarius than that in EHFV antigen-positive mice EHFV can be isolated in the lungs: ④EHFV antigen-positive Apodemus blood, urine and faecal contagious: ⑤ field surveys show that EHFV can be transmitted through the leather mites, chigger mites sting. According to the epidemiological investigation data, the precautionary measures of rodent control were drafted. Five indicators of control of the echovirus of the wild mouse type were proposed, namely: (1) the rat density was controlled below 1.0%; (2) the mouse EHFV antigen Positive rate of 3.0% or less than 5.0%; ③ rat EHFV antibody positive rate of 5.0% or less; ④ local resident healthy population EHFV antibody positive rate should be zero; ⑤EHF incidence is individual Or no patient. The findings of the past few years have further proved. Five control methods and indexes on wild-type EHF are effective and effective, that is, rodent control is the key to prevent EHF. Large-area repeated drug rodent control is the control of wild-type EHF.