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目的比较改良CTF方案与经典CTF方案对乳腺癌的疗效和不良反应。方法将115例女性乳腺癌患者随机分组,研究组采用改良CTF方案,对照组采用经典CTF方案,分别行6个周期术后常规化疗,于第4~5周期评价化疗不良反应,于术后1,3年随访评价疗效。结果改良CTF方案较经典CTF方案有较轻的骨髓抑制、消化道不良反应及肝脏损伤,且二者在术后1,3年总生存率方面差异无显著性。结论改良CTF方案较经典CTF方案化疗不良反应少,且无严重长期后遗症,疗效可靠,值得在临床推广使用。
Objective To compare the efficacy and adverse reactions of modified CTF and classic CTF in breast cancer. Methods A total of 115 female breast cancer patients were randomly divided into two groups. The study group was treated with modified CTF regimen. The control group was treated with classical CTF regimen. Six cycles of conventional chemotherapy were performed. The adverse reactions were evaluated in cycles 4 to 5. , 3-year follow-up evaluation of curative effect. Results The modified CTF regimen had less myelosuppression, gastrointestinal adverse reactions and liver damage than the classic CTF regimen. There was no significant difference in the overall survival between the two groups at 1 and 3 years after operation. Conclusion The modified CTF regimen has less adverse reactions than the classical CTF regimen and no serious long-term sequelae, which is reliable and worthy of clinical application.