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胃类癌来源于非胃窦部粘膜的肠嗜铬样(ECL)细胞,是一种罕见的肿瘤。到1977年为止,仅报道100例。然而,在有恶性贫血、萎缩性胃炎的患者中胃类癌的发生率远高于正常人群。ECL细胞系统的增生常发生于患萎缩性胃炎及卓艾综合征患者,二种病均以高胃泌素血症为其临床特征。在动物实验中,给老鼠服大剂量制酸药可引起血胃泌素水平升高,伴随ECL细胞的增生。这种情况可通过胃窦部切除来改善及预防。由此推断高胃泌素血症是ECL细胞增生的一个诱发因素。然而,人类是否如此。对患有恶性贫血及非窦性萎缩性胃炎的病人,高胃泌素血症是否可导致ECL细胞系统的增生,增生到什么程度可转变为肿瘤还不清楚。本文报道了一例患有恶性贫血,非窦性萎缩性胃炎,高胃泌素血症及广泛的ECL细胞增生伴有胃类癌的患者,涉及了组织病理学及生物化学的发
Gastric carcinoids are intestinal chromophilic (ECL) cells from the non-antral mucosa, and are a rare tumor. By 1977, only 100 cases had been reported. However, the incidence of gastric carcinoid in patients with pernicious anemia and atrophic gastritis is much higher than that in the normal population. The hyperplasia of the ECL cell system often occurs in patients with atrophic gastritis and Zhuo Ai Syndrome. Both diseases are characterized by hypergastrinemia. In animal experiments, administering large doses of antacids to mice can cause elevated blood gastrin levels, accompanied by proliferation of ECL cells. This condition can be improved and prevented by antral excision. It was concluded that hypergastrinemia is a predisposing factor for ECL cell proliferation. However, whether humans do this. For patients with pernicious anemia and non-sinus atrophic gastritis, can hypergastrinemia lead to hyperplasia of the ECL cell system and it is unclear to what extent the hyperplasia can be converted to a tumor. This article reports a case of patients with pernicious anemia, non-sinus atrophic gastritis, hypergastrinemia, and extensive ECL cell hyperplasia with gastric carcinoid, involving histopathology and biochemistry.