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利用RIA测定PRL细胞腺瘤患者血清中PRL、FSH、LH、T水平,探讨PRL细胞腺瘤过度分泌PRL对促性腺激素(GTH)以及对男性性功能的影响。结果在366例PRL细胞腺瘤患者中,159例(43.4％)血清FSH水平低于正常,148例(40.4％)血清LH水平低于正常,8例(2.18％)血清FSH水平高于正常,10例(2.7％)血清LH水平高于正常。在98例男性性功能低下的PRL细胞腺瘤患者中,血清FSH、LH水平与正常对照及性功能正常的PRL细胞腺瘤患者之间无显著性差异,而血清T水平有明显差异(P<0.01和P<0.05)。另外比较血清T/LH比值发现性功能低下组显著低于正常对照组。结果提示,PRL过渡分泌干扰下丘脑-垂体-性腺轴的功能活动,影响性腺对性激素的合成或转化,导致性功能低下。
The levels of PRL, FSH, LH, and T in the serum of patients with PRL adenoma were measured by RIA to investigate the effect of excessive PRL secretion by PRL cells on gonadotropin (GTH) and male sexual function. Results Of the 366 PRL adenomas, 159 (43.4%) had a lower serum FSH level, 148 (40.4%) had a lower serum LH level, and 8 (2.18%) had a higher FSH level than normal. Serum LH levels were higher than normal in 10 patients (2.7%). In 98 cases of male sexually dysfunctional PRL cell adenomas, there was no significant difference between serum FSH, LH levels and normal controls and normal sexual function PRL cell adenomas, but serum T levels were significantly different (P< 0.01 and P<0.05). In addition, the serum T/LH ratio was found to be significantly lower in the sexual dysfunction group than in the normal control group. The results suggest that the transitional secretion of PRL interferes with the functional activities of the hypothalamic-pituitary-gonadal axis and affects the synthesis or transformation of sex hormones on sex hormones, resulting in sexual dysfunction.