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自从一九四四年发现链霉素以来,抗结核药物不断发现:如对胺柳酸、TB_1、紫霉素等。一九五二年异烟肼问世后,由于其高效、价廉、毒性低的优点,被广泛应用至今已二十多年,仍为初治病人治疗中的重要药物。此后又有吡嗪酰胺、环丝氨酸、1314、1321、乙胺丁醇等抗痨药物,其中最令人兴奋的是甲哌力复霉素(利福平)的发现,使近年来结核病治疗跨进了一大步,该药的缺点是价钱太贵,不能广泛地推广于农村。因此,若能找到一个价廉、高效、毒性低的抗结核新药,将弥补上述不足。
Since the discovery of streptomycin in 1944, anti-TB drugs have been continuously discovered: such as amidines, TB_1, viomycin and so on. After isoniazid came into being in 1952, it has been widely used for more than 20 years because of its advantages of high efficiency, low cost and low toxicity. It is still an important drug in the treatment of untreated patients. Since then there are pyrazinamide, cycloserine, 1314,1321, ethambutol and other anti-tuberculosis drugs, the most exciting of which is mefenamicol (rifampicin) found that in recent years, the treatment of TB A big step forward, the disadvantage of this medicine is the price is too expensive, can not be widely promoted in rural areas. Therefore, if we can find a new anti-TB drug with low cost, high efficiency and low toxicity, we will make up for the above shortcomings.