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干扰素-γ是一种调节细胞功能的小分子多肽。在气道炎症反应中,Th_1细胞活化后产生的IFN-γ能抑制B细胞产生IgE、IgG_1和IgG_4参与哮喘发病。本文就IFN-γ在支气管哮喘发病及其治疗中的作用做一简要综述。
Interferon-γ is a small molecule polypeptide that regulates the function of cells. In the airway inflammatory response, IFN-γ produced by the activation of Th1 cells inhibits the production of IgE by B cells. IgG1 and IgG4 are involved in the pathogenesis of asthma. This article gives a brief overview of IFN-γ in the pathogenesis and treatment of bronchial asthma.