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目的探讨肝硬化合并肝源性糖尿病的临床特点。方法对肝源性糖尿病52例患者的临床特点、发病机制及预后进行分析。结果肝硬化发生肝源性糖尿病发病率为31.0%,多见于男性,通过饮食控制、护肝、胰岛素降血糖等治疗,疗效大多较佳。结论肝硬化易发生糖代谢紊乱,最终发展为糖尿病,发生机制与胰岛素抵抗等因素有关,肝源性糖尿病早期通过护肝、饮食控制、胰岛素降血糖等综合治疗疗效大多较好,对肝硬化患者早期检测血糖是避免漏诊的关键。
Objective To investigate the clinical features of liver cirrhosis complicated with liver-derived diabetes. Methods The clinical features, pathogenesis and prognosis of 52 patients with liver-derived diabetes mellitus were analyzed. Results The incidence of liver-derived diabetes in cirrhosis was 31.0%, which was more common in males. The therapeutic effects were mostly better through diet control, liver protection and hypoglycemic insulin therapy. Conclusions Liver cirrhosis is prone to disorder of glucose metabolism and eventually to diabetes. The pathogenesis is related to insulin resistance and other factors. Early treatment of liver-derived diabetes through liver protection, diet control and insulin hypoglycemic treatment are mostly effective. Patients with cirrhosis Early detection of blood glucose is the key to avoiding missed diagnosis.