围生期窒息可引起机体多器官功能损害 ,其中以肾损伤的发生率最高。肾损伤的机制尚不清楚 ,可能与窒息后缺氧再灌注损伤有关。我们的前期工作已显示新生鼠窒息后肾组织产生白细胞介素 8(ＩＬ 8)、肿瘤坏死因子 α(ＴＮＦ α)等炎症细胞因子增加 ,且与肾小管损伤呈正相关。本 Perinatal asphyxia can cause multiple organ dysfunction, of which the highest incidence of renal injury. The mechanism of renal injury is not clear, may be related to hypoxia-reperfusion injury after asphyxia. Our previous work has shown that neonatal rats with asphyxia produce increased levels of interleukin 8 (IL 8) and inflammatory cytokines such as tumor necrosis factor α (TNF α), which are positively correlated with renal tubular injury. this