A single electron transistor based on a silicon-on-insulator is successfully fabricated with electron-beam nanolithography,inductively coupled plasma etching,thermal oxidation and other techniques.The unique design of the pattern inversion is used,and the pattern is transferred to be negative in the electron-beam lithography step.The oxidation process is used to form the silicon oxide tunneling barriers,and to further reduce the effective size of the quantum dot.Combinations of these methods offer advantages of good size controllability and accuracy,high reproducibility,low cost,large-area contacts,allowing batch fabrication of single electron transistors and good integration with a radio-frequency tank circuit.The fabricated single electron transistor with a quantum dot about 50nm in diameter is demonstrated to operate at temperatures up to 70K.The charging energy of the Coulomb island is about 12.5meV. A single electron transistor based on a silicon-on-insulator is successfully fabricated with electron-beam nanolithography, inductively coupled plasma etching, thermal oxidation and other techniques. The unique design of the pattern inversion is used, and the pattern is transferred to be negative in the electron-beam lithography step. and the further reduction of the effective size of the quantum dot. Combinations of these methods offer advantages of good size controllability and accuracy, high reproducibility, low cost, large-area contacts, allowing batch fabrication of single electron transistors and good integration with a radio-frequency tank circuit. fabricated fabricated electron tube with a quantum dot about 50 nm in diameter is demonstrated to operate at temperatures up to 70K. charging energy of the Coulomb island is about 12.5meV.