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目的应用头颈部肿瘤患者生存质量测定量表(FACT-H&N)对鼻咽癌患者生存质量进行测评。方法选取中山大学肿瘤医院确诊的鼻咽癌患者444例,采用FACT-H&N量表进行生存质量测评,同时评价量表信度与效度。结果治疗中患者生理状况得分为(19.08±5.454)分;功能状况得分为(14.00±5.490)分;头颈部附加条目得分为(20.11±6.052)分;量表总得分为(95.18±18.360)分;均低于治疗前和治疗后得分;治疗后患者头颈部附加条目得分和生存质量总得分虽比治疗中有所上升,但未恢复至治疗前水平;量表内部一致性信度(克朗巴赫系数)为0.899,量表各领域的克朗巴赫系数(Cronbachα)为0.692～0.859;生理状况、功能状况和头颈部附加条目3个领域的重测相关系数(r)均>0.5,相关性良好;提取5个公因子的累积方差贡献率为61%,与量表设计基本吻合。结论治疗中的鼻咽癌患者生存质量明显下降;FACT-H&N量表可用于鼻咽癌患者生存质量测定和相关研究。
Objective To evaluate the quality of life of patients with nasopharyngeal carcinoma (NPC) by using FACT-H & N Scale. Methods Forty-four patients with nasopharyngeal carcinoma confirmed by Cancer Hospital of Sun Yat-sen University were enrolled. The quality of life was evaluated by FACT-H & N scale. The reliability and validity of the scale were also evaluated. Results The score of physical status in the treatment group was (19.08 ± 5.454) points, the functional status score was (14.00 ± 5.490), the head and neck additional item score was (20.11 ± 6.052), the scale score was (95.18 ± 18.360) Points were lower than before treatment and after treatment scores; head and neck additional items after treatment score and quality of life scores of total score than the treatment has increased, but did not return to pre-treatment levels; scale internal consistency reliability ( Cronbach’s coefficient was 0.899, and Cronbachα was 0.692-0.859 in all fields. The correlation coefficients (r) of physiological status, functional status and head and neck additional items were all higher than 0.5 in all three fields The goodness was good. The cumulative variance contribution of 5 common factors was 61%, which was in good agreement with the scale design. Conclusions The quality of life of patients with nasopharyngeal carcinoma under treatment is obviously decreased. The FACT-H & N scale can be used to measure the quality of life of patients with nasopharyngeal carcinoma and its related research.