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目的:研究黄芪总甙(astragalosides,AST)延缓衰老的作用及其机制。方法:采用小鼠D-半乳糖(D-galactose,D-gal)人工衰老模型和自然衰老模型(17月龄),以小鼠协调运动、学习记忆、以及免疫功能作为指标,同步观察药物的作用。结果:AST(40mg·kg~(-1)·d~(-1),ig,10周)可明显恢复D-gal衰老小鼠的协调运动和学习记忆功能,使其过低的ConA诱导脾淋巴细胞增殖反应及IL-2产生明显升高,但对LPS诱导B淋巴细胞增殖反应无明显影响。AST(40mg·kg~(-1)·d~(-1),ig,3个月)对17月龄小鼠亦有类似作用。结论:AST对D-gal衰老小鼠和由中年期(14月龄)进入老前期(17月龄)小鼠的自然衰老进程均有明显的延缓作用,可能与其免疫调节作用有关。
Objective: To study the effect of astragalosides (AST) on anti-aging and its mechanism. METHODS: The mouse D-galactose (D-gal) artificial aging model and the natural aging model (17 months old) were used to observe the drug’s coordination activity, learning and memory, and immune function as indicators. effect. RESULTS: AST (40 mg·kg -1 ·d -1 ), ig, 10 weeks, significantly restored the coordination movement and learning and memory function of D-gal aging mice, making it too low for ConA-induced spleen. Lymphocyte proliferation and IL-2 production were significantly increased, but there was no significant effect on LPS-induced B lymphocyte proliferation. AST (40 mg·kg -1 ·d -1), ig, 3 months also had a similar effect on 17-month-old mice. CONCLUSION: AST significantly delays the natural aging process in D-gal aging mice and in middle-aged (14-month-old) mice into the pre-adult (17-month-old) mice, which may be related to their immunomodulatory effects.