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目的探讨米非司酮配伍米索前列醇终止中期妊娠的效果。方法 254例中期妊娠孕妇随机分为治疗组和对照组,治疗组用米非司酮加米索前列醇,对照组用米非司酮加依沙吖啶。比较两组胎儿、胎盘娩出时间以及总产程、清宫率、引产成功率及产后出血量。结果治疗组胎儿、胎盘娩出时间及产程、产后出血量分别为(25.63±5.39)h、(6.43±3.37)h、(103.21±29.67)ml;对照组胎儿、胎盘娩出时间及产程、产后出血量分别为(26.13±4.97)h、(8.12±3.26)h、(137.19±31.28)ml。治疗组清宫率为9.92%,对照组清宫率18.70%,两组引产成功率均为100.00%。结论米非司酮配伍米索前列醇用于中期引产疗效肯定、总产程短、出血量少、清宫率低,值得推广。
Objective To investigate the effect of mifepristone and misoprostol on termination of mid-term pregnancy. Methods 254 pregnant women of middle pregnancy were randomly divided into treatment group and control group. Mifepristone plus misoprostol was used in the treatment group and mifepristone plus ethacridine in the control group. Comparison of two groups of fetuses, placenta delivery time and total labor, clearance rate, induction of labor success rate and postpartum hemorrhage. Results The fetus and placenta delivery time and the amount of postpartum hemorrhage were (25.63 ± 5.39) h and (6.43 ± 3.37) h and (103.21 ± 29.67) ml respectively in the treatment group. The fetus and placenta delivery time and labor, postpartum hemorrhage volume (26.13 ± 4.97) h, (8.12 ± 3.26) h, (137.19 ± 31.28) ml, respectively. The cure rate was 9.92% in the treatment group and 18.70% in the control group, with 100.00% success rate in both groups. Conclusions Mifepristone and misoprostol are effective for mid-term induction of labor with short total length of labor, less bleeding, and low rate of debridement, which deserves promotion.