Motivated by the fact that Weyl fermions can emerge in a three-dimensional topological insulator on breaking either time-reversal or inversion symmetries,we propose that a topological quantum phase transition to a Weyl semimetal phase occurs under the off-resonant circularly polarized light,in a three-dimensional topological insulator,when the intensity of the incident light exceeds a critical value.The circularly polarized light effectively generates a Zeeman exchange field and a renormalized Dirac mass,which are highly controllable.The phase transition can be exactly characterized by the first Chem number.A tunable anomalous Hall conductivity emerges,which is fully determined by the location of the Weyl nodes in momentum space,even in the doping regime.Our predictions are experimentally realizable through pump-probe angle-resolved photoemission spectroscopy and raise a new way for realizing Weyl semimetals and quantum anomalous Hall effects.