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目的探讨一氧化氮(nitricoxide,NO)介导的细胞因子失衡 ,在儿童慢性淋巴细胞性甲状腺炎(CLT)发病中的作用。方法对初诊(CLT)患儿13例外周血单个核细胞(PBMC)产生的NO水平及其与IFN γ和IL 4水平失衡和甲状腺功能受损的关系进行了研究。结果与正常组相比 ,患儿NO和IFN γ水平明显升高(P<0.001) ,IL 4的水平明显降低(P<0.002) ;NO水平与IFN γ和血清TSH水平呈显著的正相关(P<0.05) ,而与IL 4及血清T3 ,T4的水平呈显著的负相关(P<0.05)。结论NO作为细胞因子水平失衡的介质 ,参与了CLT的发病。
Objective To investigate the role of nitric oxide (NO) -based cytokine imbalance in the pathogenesis of childhood chronic lymphocytic thyroiditis (CLT). Methods The levels of NO produced by peripheral blood mononuclear cells (PBMCs) from 13 newly diagnosed children (CLT) and their relationship with the imbalance of IFN-γ and IL-4 and thyroid dysfunction were studied. Results Compared with the normal control group, NO and IFN γ levels in children were significantly increased (P <0.001), IL 4 level was significantly lower (P <0.002), NO levels were positively correlated with IFN γ and serum TSH level P <0.05), but negatively correlated with the levels of IL-4 and serum T3 and T4 (P <0.05). Conclusion As a mediator of cytokine imbalance, NO participates in the pathogenesis of CLT.