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目的了解我国2004—2010年艾滋病母婴传播及母婴阻断药物应用状况。方法全面检索中国生物医学文献数据库(CBM)和PubMed等中英文数据库中中国艾滋病母婴传播相关文献,检索时间均从建库到2013年5月。对纳入的文献采用参照AHRQ横断面研究评价标准和STROBE声明拟定的4条标准进行质量评价。将样本量、监测地点和监测年份作为主要异质性来源进行meta回归分析。采用Comprehensive Meta-Analysis V2.0software进行meta分析。结果共检索到2 356篇文献,最终纳入51篇进行分析。2004—2010年我国艾滋病母婴传播率依次分别为12.90%(95%CI:7.48%~21.36%)、16.35%(95%CI:10.41%~24.73%)、6.45%(95%CI:3.73%~10.93%)、6.25%(95%CI:2.39%~15.36%)、5.56%(95%CI:2.79%~10.76%)、3.10%(95%CI:1.59%~5.97%)、2.29%(95%CI:1.36%~3.83%),孕产妇中阻断药物应用率依次分别为70.39%(95%CI:24.42%~94.59%)、71.99%(95%CI:61.49%~80.54%)、78.79%(95%CI:70.19%~85.43%)、86.84%(95%CI:79.24%~91.94%)、82.71%(95%CI:76.62%~87.48%)、81.85%(95%CI:75.55%~86.80%)、86.16%(95%CI:53.20%~97.15%);2005—2010年婴儿阻断药物应用率依次分别为80.72%(95%CI:72.89%~86.70%)、81.84%(95%CI:71.55%~88.98%)、85.43%(95%CI:80.99%~88.97%)、89.75%(95%CI:81.82%~94.45%)、92.39%(95%CI:84.97%~96.31%)、90.34%(95%CI:85.50%~93.68%)。结论近年来我国艾滋病母婴传播率呈下降趋势,孕产妇及婴儿阻断药物应用率都有所升高。
Objective To understand the status of mother-to-child transmission and maternal and child blockage in China from 2004 to 2010. Methods A comprehensive search of relevant literature on mother-to-infant transmission of HIV / AIDS in China in the Chinese and English databases of China Biomedical Literature Database (CBM) and PubMed was conducted. The search time was from the database to May 2013. The quality of the included literature was evaluated by reference to the four criteria developed by the AHRQ Cross-sectional Study Evaluation Criteria and the STROBE Statement. The sample size, monitoring sites and monitoring years as the main source of heterogeneity meta-regression analysis. Comprehensive Meta-Analysis V2.0software for meta-analysis. Results A total of 2 356 articles were retrieved and finally 51 articles were included for analysis. The rates of mother-to-child transmission of AIDS in China from 2004 to 2010 were 12.90% (95% CI: 7.48% ~ 21.36%), 16.35% (95% CI: 10.41% ~ 24.73%), 6.45% (95% CI: 2.39% to 15.36%), 5.56% (95% CI: 2.79% to 10.76%), 3.10% (95% CI: 1.59% to 5.97%), 2.29% 95% CI: 1.36% -3.83%). The rates of blocking drugs in pregnant women were 70.39% (95% CI: 24.42% ~ 94.59%), 71.99% 78.79% (95% CI: 70.19% -85.43%), 86.84% (95% CI: 79.24% -91.94%), 82.71% (95% CI: 76.62% ~ 87.48%), 81.85% (95% CI: 53.20% -97.15%). The rates of infantile blockade in 2005-2010 were 80.72% (95% CI: 72.89% -86.70%) and 81.84% (95% CI: (95% CI: 81.52% -94.45%), 85.43% (95% CI: 80.99% ~ 88.97%), 89.75% (95% CI: 81.82% ~ 94.45%), 92.39% %), 90.34% (95% CI: 85.50% ~ 93.68%). Conclusions In recent years, the rate of mother-to-child transmission of HIV / AIDS in China has been on a downward trend, and the utilization rate of maternal and infant blockage drugs has risen.