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目的:探讨中医药治疗小儿呼吸道合胞病毒(RSV)肺炎的临床有效性和安全性。方法:采用随机、平行对照的原则,将114例患儿分为两组,试验组静滴清开灵注射液,痰热闭肺证口服儿童清肺口服液,风热闭肺证口服小儿咳喘灵口服液;对照组静滴利巴韦林注射液,口服复方愈创木酚磺酸钾口服液,疗程10d。对所得数据进行卡方检验、秩和检验或t检验。结果:临床疾病疗效评价结果:试验组愈显率87.72%,对照组71.93%,差异有统计学意义(P<0.05)。以治疗前后主症积分的差值对主症进行疗效再评价,结果两组在咳嗽、气促、肺部听诊、胸部X线片方面,差异有高度统计学意义(P<0.01),试验组优于对照组。以治疗前后主症积分之和进行比较,结果两组在发热、痰壅方面差异有统计学意义(P<0.05)。两组安全性评价结果显示:试验组显著优于对照组(P<0.01)。结论:中医药治疗小儿RSV肺炎具有良好的有效性和安全性。
Objective: To investigate the clinical efficacy and safety of traditional Chinese medicine in the treatment of children with respiratory syncytial virus (RSV) pneumonia. Methods: A randomized, parallel control principle, the 114 children were divided into two groups, the experimental group intravenous Qingkailing injection, phlegm and lung closed oral oral Qingfei oral liquid, wind and heat lungs oral administration of pediatric cough Asthma oral liquid; control group intravenous infusion of ribavirin, oral compound guaiacol sulfonate oral solution, treatment 10d. The data were chi-square test, rank sum test or t test. Results: The results of clinical disease evaluation showed that the cure rate of the experimental group was 87.72% and that of the control group was 71.93%, the difference was statistically significant (P <0.05). The difference of the main symptom scores before and after treatment was used to evaluate the main symptoms. The results showed that there was a statistically significant difference between the two groups in cough, shortness of breath, auscultation of the lungs and chest radiographs (P <0.01) Better than the control group. The main symptom scores before and after treatment were compared, the results of the two groups in the fever, sputum 壅 the difference was statistically significant (P <0.05). Two groups of safety evaluation results show that: the experimental group was significantly better than the control group (P <0.01). Conclusion: Chinese medicine treatment of children with RSV pneumonia has good effectiveness and safety.