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肿瘤骨转移会产生顽固性骨痛和脊髓受压等严重并发症,并对分期、治疗和判断预后产生深远的影响,因而探测骨转移是制定治疗计划的重要部分。骨转移瘤发现频率因原发肿瘤的类型和所用检查手段不同而不同,虽然目前核素骨扫描是探测骨转移瘤最常用的手段,但其对骨转移瘤的诊断效能仍有一定限度。与99mTc-亚甲基二膦酸盐(99mTc—MDP)骨显像相比,18F-氟化钠(18F— NaF)和18F-氟代脱氧葡萄糖(18F—FDG)PET是分别从骨转移瘤产生的成骨反应和骨转移瘤本身的代谢活性角度进行评价的两种正电子示踪剂,结合PET的高度空间分辨率,特别是最近迅速应用于临床的PET—CT技术,使得正电子体层显像在全身骨骼恶性疾病评价上的准确性进一步提高。
Tumor metastases can produce serious complications such as intractable bone pain and spinal cord compression, and have a profound impact on staging, treatment, and prognosis. Therefore, detecting bone metastases is an important part of planning treatment. The frequency of bone metastases found varies depending on the type of primary tumor and the method used. Although radionuclide bone scan is currently the most commonly used method to detect bone metastases, its diagnostic efficacy for bone metastases still has a certain limit. Compared with 99mTc-methylene diphosphonate (99mTc-MDP) bone imaging, 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) PET are metastatic bone tumors, respectively. The two positron tracers evaluated for the osteogenic response and the metabolic activity of the bone metastasis itself, combined with the high spatial resolution of PET, especially the PET-CT technology that has recently been rapidly applied clinically, makes the positron The scintigraphy further improves the accuracy of the assessment of systemic bone malignancy.