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目的观察诺维本(NVB)与顺铂(DDP)组成的NP方案与丝裂霉素(MMC)、长春地辛(VDS)、DDP组成的MVP方案对晚期非小细胞肺癌(NSCLC)的近期疗效和毒副反应。方法将2003年2月至2005年2月在解放军总医院第二附属医院肿瘤科治疗的经病理组织学或细胞学证实的晚期NSCLC患者63例,随机分为A组(32例)和B组(31例)分别实施NP方案及MVP方案治疗,21d为1个治疗周期。观察2种治疗方案的有效率及毒副反应情况。结果A组有效率为40.63%,B组32.26%,两组比较P>0.05。主要毒副反应为骨髓抑制、胃肠道反应、周围神经毒性及静脉炎。结论NP与MVP方案的近期疗效大致相同,毒副反应差异无统计学意义,2种方案均可作为NSCLC的一线治疗方案。
Objective To observe the effect of MVP regimen consisting of NP regimen consisting of NVB and DDP combined with mitomycin C (MMC), vindesine (VDS) and DDP on advanced non-small cell lung cancer (NSCLC) Efficacy and side effects. Methods Sixty-three patients with pathologically confirmed or cytologically advanced NSCLC who were treated in Department of Oncology, Second Affiliated Hospital of PLA General Hospital from February 2003 to February 2005 were randomly divided into two groups: group A (n = 32) and group B (31 cases) were treated with NP regimen and MVP regimen respectively, and 21 days was treated by one cycle. Observe the efficiency and toxicity of the two treatment options. Results The effective rate was 40.63% in group A and 32.26% in group B, P> 0.05. The main side effects are myelosuppression, gastrointestinal reactions, peripheral neurotoxicity and phlebitis. Conclusions The NP and MVP regimens have the similar short-term curative effects. There is no significant difference in the side effects between the NP and MVP regimens. Both regimens can be used as first-line regimens for NSCLC.