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目的:探讨人表皮生长因子受体-2(HER-2)和环氧合酶-2(COX-2)在胃癌组织中的表达及与临床病理特征的关系。方法:应用免疫组化Envision二步法,检测70例胃癌组织和40例正常胃组织中HER-2及COX-2的表达情况,并结合其临床病理特点进行分析。结果:(1)HER-2在胃癌中的阳性率为27.1%,在正常胃组织的阳性率为5%;COX-2在胃癌中的阳性率为67.1%,正常胃组织阳性率为22.5%。两种蛋白分别在胃癌及正常组织中的表达差异具有统计学意义(P<0.05,P<0.01)。(2)HER-2及COX-2在胃癌组织中的阳性表达与肿瘤分化程度、侵袭深度、有无淋巴结转移及TNM分期有关(P<0.05),而与患者的性别及年龄、肿瘤部位和大小无关(P>0.05)。(3)HER-2与COX-2在胃癌组织中的表达呈正相关(P<0.05)。结论:HER-2及COX-2的表达参与胃癌的生长、侵袭和转移过程,在胃癌的预后中扮演了重要角色。
Objective: To investigate the expression of human epidermal growth factor receptor-2 (HER-2) and cyclooxygenase-2 (COX-2) in gastric carcinoma and its relationship with clinicopathological features. Methods: The expressions of HER-2 and COX-2 in 70 gastric cancer tissues and 40 normal gastric tissues were detected by immunohistochemistry Envision two-step method and analyzed with clinicopathological features. Results: (1) The positive rate of HER-2 in gastric cancer was 27.1% and that in normal gastric tissue was 5%. The positive rate of COX-2 in gastric cancer was 67.1% and that in normal gastric tissue was 22.5% . The differences of the expression of the two proteins in gastric cancer and normal tissues were statistically significant (P <0.05, P <0.01). (2) The positive expression of HER-2 and COX-2 in gastric cancer was related to the degree of tumor differentiation, invasion depth, lymph node metastasis and TNM staging (P <0.05), but not with the gender and age, tumor location and Size has nothing to do (P> 0.05). (3) There was a positive correlation between HER-2 and COX-2 expression in gastric cancer (P <0.05). Conclusion: The expressions of HER-2 and COX-2 are involved in the growth, invasion and metastasis of gastric cancer and play an important role in the prognosis of gastric cancer.