论文部分内容阅读
目的:研究透明带形态异常卵母细胞的受精、胚胎发育和临床结局。方法:以在IVF完全受精失败(TFF)周期中透明带形态异常的15名患者为研究组(A组),非透明带形态异常的完全受精失败周期的63例患者为对照组(B组),回顾性分析比较患者的一般临床情况、IVF结局及行补救ICSI(R-ICSI)的临床结局。结果:除受精率组间有显著性差异(65.52%vs 78.86%,P<0.01)外,其余各指标(年龄、不孕年限、不孕类型、不孕原因、基础内分泌水平、基础卵泡数、降调节天数、Gn使用天数、Gn使用总量、hCG注射日直径≥16 mm卵泡数、hCG注射日E2、P和LH水平、获卵数、MII卵数、行R-ICSI的受精率、卵裂率、优质胚胎率、种植率、临床妊娠率和流产率)组间均无统计学差异。结论:IVF完全受精失败周期透明带形态异常卵母细胞行R-ICSI虽受精率较低,但及早发现受精失败并行R-ICSI,可使65.52%的卵子受精,从而改善临床结局。
Objective: To study the fertilization, embryo development and clinical outcome of abnormal zona pellucida oocytes. Methods: A total of 15 patients with morphologic abnormalities of the zona pellucida (IVF) during the period of complete fertilization failure (IVF) were enrolled as control group (group A) , Retrospective analysis and comparison of the general clinical situation of patients, IVF outcomes and clinical outcomes of ICSI (R-ICSI). Results: In addition to significant differences between fertilization groups (65.52% vs 78.86%, P <0.01), the other indicators (age, duration of infertility, types of infertility, causes of infertility, basal endocrine levels, basal follicles, The number of days of down regulation, the number of days of Gn use, the total amount of Gn use, the number of follicles with a diameter of ≥ 16 mm on day of hCG injection, the level of E2, P and LH on day of hCG injection, the number of oocytes retrieved, the number of MII eggs, Split rate, high quality embryo rate, implantation rate, clinical pregnancy rate and abortion rate) were not statistically different between groups. Conclusion: IVF complete fertilization failure cycle zona pellucida morphologically abnormal oocyte R-ICSI Although the fertilization rate is low, but the early detection of fertilization failure parallel R-ICSI, 65.52% of eggs can be fertilized, thereby improving the clinical outcome.