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目的：研究亚低温对严重脑缺血再灌注早期神经功能和脑组织形态学的影响，探讨亚低温脑复苏效果。方法：采用犬心脏停跳１８分钟再复苏模型。１５只杂种犬随机分成３组：非缺血对照组（４只）、常温治疗组（５只）和亚低温（３３．５～３４．５℃）治疗组（６只）。观察神经功能综合评分和形态学损害程度分级等指标。结果：常温治疗组与亚低温治疗组对循环复苏时主要参数的影响无统计学差异，亚低温治疗后脑组织病理损伤程度较常温治疗组为轻〔神经功能综合评分分别为（１３．４±１．３）分和（１７．３±０．８）分〕。结论：亚低温能明显减轻脑组织形态学和神经功能损害，提示亚低温有脑复苏效果。
Objective: To study the effects of mild hypothermia on neurological function and brain histomorphology in patients with severe cerebral ischemia-reperfusion and to explore the effect of mild hypothermia cerebral resuscitation. Methods: The dogs were beaned for an 18-minute resuscitation. Fifteen mongrel dogs were randomly divided into three groups: non-ischemic control group (n = 4), normal temperature treatment group (n = 5) and mild hypothermia (33.5 ~ 34.5 ℃) treatment group (n = 6). Observe the comprehensive index of neurological function and the degree of morphological damage and other indicators. Results: There was no significant difference in the main parameters of circulatory resuscitation between normal temperature group and mild hypothermia group, and the pathological damage of mild brain tissue after mild hypothermia was lighter than that of normal temperature group (the neurological functional scores were (13.4 ± 1) .3) points and (17.3 ± 0.8) points]. Conclusion: Mild hypothermia can significantly reduce brain damage in morphology and nerve function, suggesting that mild hypothermia cerebral recovery effect.