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树突状细胞 (DC)在体内的迁移过程是DC发挥其生物学功能的前提。近年来 ,趋化因子作为DC在体内迁移的重要调控者得到了进一步的认识。趋化因子连接了DC介导的由天然免疫向获得性免疫的转变过程 ;趋化因子通过调控粘附分子的激活和激活的时序辅助DC的迁移 ;DC成熟过程中 ,其本身趋化因子及其受体表达的变化更是其实现向二级淋巴器官迁移的必要条件。另外 ,某些脂质转运蛋白 (如MDR1及MRP1)也可以通过激活趋化因子受体的表达来调控DC的迁移。
The process of dendritic cells (DCs) migration in vivo is a prerequisite for DCs to exert their biological functions. In recent years, chemokines have been further recognized as important regulators of DC migration in vivo. Chemokine binds to DC-mediated transition from innate immunity to acquired immunity. Chemokines assist DC migration by regulating the activation and activation of adhesion molecules. In DC maturation, chemokines themselves and The changes of its receptor expression is more necessary to achieve its migration to secondary lymphoid organs. In addition, some lipid transporters (such as MDR1 and MRP1) can also regulate DC migration by activating the expression of chemokine receptors.