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目的世界银行贷款中国结核病控制项目首次将全间歇短程化疗（短化）方案［２Ｈ３Ｒ３Ｚ３Ｓ３（Ｅ３）／４Ｈ３Ｒ３］应用于国家结核病控制规划，取得了满意的近期疗效。为评价方案的有效性，特进行远期效果观察。方法对１２个项目省、自治区５６个示范县１９９２年全年登记的新发涂阳患者，在治愈后２年进行了结核分支杆菌涂片检查，以了解细菌学复发情况。结果４４００例治愈患者经痰涂片检查，发现１３５例痰菌复阳，复发率为３．１％。结论本研究与国内外短化每日疗法与继续期间歇的６个月短化方案相比，其复发率相近。证明本方案治愈率高（复发率在３％左右），不失为一个可优先推广应用于国家结核病规划的化疗方案之一。
Purpose The World Bank-China TB Control Project has for the first time put the whole-batch short-course chemotherapy (shortening) program [2H3R3Z3S3 (E3) / 4H3R3] into the national tuberculosis control program and has achieved satisfactory short-term curative effect. To evaluate the effectiveness of the program, special observation of long-term effects. Methods Twelve new smear-positive smear positive cases registered in 1992 in all 12 demonstration provinces and autonomous regions in China were examined for smear of Mycobacterium tuberculosis 2 years after the cure to understand the bacteriological recurrence. Results 4400 cases of cured patients by sputum smear examination and found that 135 cases of sputum bacilli, the recurrence rate was 3.1%. Conclusions This study is similar to both short daily therapy and discontinuous intermittent 6-month shortening regimen at home and abroad. Proves that the cure rate of this program is high (the recurrence rate is about 3%), after all, one of the chemotherapy regimens that can be applied preferentially to the national tuberculosis program.