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Piccini等报道10年前接受胚胎黑质移植的帕金森病病人多巴胺释放已恢复到正常水平,并且临床症状已明显改善。在1989年,Piccini等将分离的中脑腹面组织(取自常规吸宫术流产的人胚胎)移植到一位对常规治疗无效的59岁男性帕金森病病人的右壳核。术后前3年病人临床症状有明显改善,分别于32和64个月停用了左旋多巴和免疫抑制性药物。然而,由于移植物同侧肢体和某些症状的出现在74个月后重新使用低剂量的左旋多巴,并且治疗反应良好,此后运动原功能及左旋多巴剂量保持不变。10年后,他没有僵直,仅有轻度的活动性降低和停顿震颤,但病情无反复。
Piccini et al. Reported that dopamine release in Parkinson’s disease patients who received embryonic substantia nigra transplants 10 years ago has returned to normal levels and clinical symptoms have been significantly improved. In 1989, Piccini et al. Isolated the isolated mesencephalic tissue of the ventral brain (from a human embryo of a conventional abortion) to a right putamen in a 59-year-old male Parkinson’s disease patient ineffective with conventional therapy. Clinical symptoms were significantly improved in the first 3 years after surgery, with levodopa and immunosuppressive drugs discontinued at 32 and 64 months, respectively. However, since the low dose of levodopa was reused after 74 months due to the ipsilateral limb graft and some symptoms, and the treatment responded well, the motor function and levodopa dose remained unchanged afterwards. Ten years later, he was free from stiffness, with only modest reductions in activity and pacing, but without recurrence.