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目的观察多西他赛(DTX)联合顺铂(DDP)和替加氟(FT-207)对进展期胃癌的近期疗效和不良反应。方法对经病理学或细胞学确诊的24例进展期胃癌患者采用DTX 75mg/m2第1,8天ivgtt,DDP 20mg/m2第1~5天ivgtt,FT-207 500mg/m2第1~5天ivgtt方案化疗,21天为1周期,所有患者均接受至少2个周期治疗后评价疗效。结果全组病例均可评价疗效:CR 1例,PR 12例,SD 5例,PD 6例;近期客观有效率54.2%。其中初治15例,CR 1例,PR 7例,总有效率53.3%;复治患者为9例,CR 0例,PR 4例,总有效率44.4%。主要不良反应为骨髓抑制、恶心呕吐和脱发。结论DTX联合DDP和FT-207治疗进展期胃癌疗效肯定,不良反应轻,耐受性好,初治疗效优于复治,值得临床进一步扩大研究。
Objective To observe the short-term effects and side effects of docetaxel (DTX) combined with cisplatin (DDP) and tegafur (FT-207) on advanced gastric cancer. Methods Twenty-four patients with advanced gastric cancer confirmed by pathology or cytology were treated with DTX 75 mg / m 2 iv ivtt, DDP 20 mg / m 2 ivgtt, and FT-207 500 mg / m 2 day 1 to day 5 ivgtt regimen chemotherapy, 21 days for a cycle, all patients received at least 2 cycles after treatment to evaluate the efficacy. Results The curative effect was evaluated in all the cases: CR 1, PR 12, SD 5 and PD 6, and the objective effective rate was 54.2% in the near future. Among them, 15 cases were newly diagnosed, 1 case had CR and 7 cases had PR, with a total effective rate of 53.3%. There were 9 cases of retreatment, 0 cases of CR and 4 cases of PR. The total effective rate was 44.4%. The main adverse reactions were myelosuppression, nausea, vomiting and hair loss. Conclusions DTX combined with DDP and FT-207 in the treatment of advanced gastric cancer has definite effect, mild adverse reactions, good tolerability and better curative effect than initial relapse. It deserves further clinical study.