清道夫受体 A(SR- A)是清道夫膜受体家族成员之一 ,主要存在于巨噬细胞 ,最初是作为脂蛋白受体被发现的 ,可以内吞修饰后的脂蛋白 ,促使动脉粥样硬化斑块形成。近年研究发现 ,SR- A还在介导巨噬细胞对内毒素内吞、清除及凋亡细胞的识别、吞噬等机体防御反应中起重要作用 Scavenger receptor A (SR-A), a member of the scavenger membrane receptor family and mainly found in macrophages, was initially found as a lipoprotein receptor that can endocytose modified lipoproteins and promote arterial Atherosclerotic plaque formation. In recent years, studies have found that SR-A is still mediating macrophages endotoxin endocytosis, clearance and apoptosis of cell recognition, phagocytosis and other body defense response plays an important role