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为考核国产伤寒Vi多糖疫苗在现场试验的效果 ,以A群脑膜炎球菌多糖疫苗为对照 ,对广西壮族自治区河池市城市和农村的 5～ 6 0岁居民进行了一次大规模接种。结果显示 :应接种对象 1180 71人 ,实际接种 92 4 76人 ,接种率为 78 32 % ,其中伤寒Vi多糖疫苗为 76 87% ,A群脑膜炎球菌多糖疫苗为 79 6 9% ;接种率最高的组群接种率为 92 4 8% ,最低为 6 5 2 0 %。按城乡划分 ,城区的接种率为 77 2 9% ,农村的接种率为 80 5 8% ,组群接种率的高低分布无明显的地理性差异。 5～ 9岁接种率最高为 89 6 5 % ,2 0～ 2 9岁接种率最低为 6 9 0 7% ;男女接种率分别为79 0 7%和 82 11%。有 6 6人被观察到或报告出现不良反应 ,不良反应发生率为 71 37/ 10万。表明两种疫苗的安全性好。在大规模疫苗接种中 ,充分发挥当地干部的宣传组织作用 ,并把接种的有关信息提前通知当地居民 ,对于提高接种率十分重要。补漏接种能使接种率低的组群得到显著的提高。在大规模疫苗接种中必须严格遵守安全注射操作程序 ,避免发生不安全注射事故。两种疫苗的平均接种率、年龄别接种率、性别接种率、组群接种率的地理分布均达到了较好均衡性 ,是可比的 ,为今后考核疫苗效果提供了良好的现场背景
In order to assess the effect of domestic-made typhoid Vi polysaccharide vaccine in the field test, A group of meningococcal polysaccharide vaccine was used as a control to conduct a large-scale inoculation of 5-60-year-old residents in Hechi City and rural areas of Guangxi Zhuang Autonomous Region. The results showed that 118071 people should be inoculated and 92,476 people were actually inoculated with the vaccination rate of 78.32%, among which, the vaccination rate of typhoid Vi polysaccharide was 76.87% and the meningococcal polysaccharide vaccine group A was 79.69% The group vaccination rate was 92 48%, the lowest was 6520%. By urban-rural division, the coverage rate in urban areas was 77 2 9% and the coverage rate in rural areas was 80 5 8%. There was no obvious geographical difference in the distribution of group vaccination rates. The highest vaccination rate was 89 6 5% at 5-9 years old and 69.07% at 20-29 years old. The male and female vaccination rates were 79 0 7% and 82 11% respectively. Sixty-six people were observed or reported adverse reactions, the incidence of adverse reactions was 71 37/10 million. The safety of both vaccines is good. In large-scale vaccination, giving full play to the role of propaganda organization of local cadres and informing local residents about the information about inoculation in advance is very important for raising the vaccination rate. Trap vaccination can make vaccination rate of the group was significantly improved. In large-scale vaccination must strictly comply with safety injection procedures to prevent unsafe injection accident. The average vaccination rate, age-specific vaccination rate, gender vaccination rate and population coverage rate of the two vaccines reached a good balance, which was comparable and provided a good on-site background for assessing the vaccine effect in the future