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早在50年代初期Nelson曾先后于体外与体内试验中观察到微生物与其相应的抗体及补体结合形成的复合物能粘附于正常人、猴、狒狒等的红细胞上,从而增强白细胞的吞噬,并认为此种免疫粘附现象是宿主防御机制的一部分。本世纪60-70年代对淋巴系统的免疫功能进行了深入的研究,但红细胞的免疫功能未予以足够重视。1981年Siegel等提出红细胞免疫功能的新概念,假设红细胞也是免疫系统必需成分之一。但对其机制、调节因素、遗传以及与疾病的关系等均有待进一步探讨。兹就现有材料作一简单介绍。
As early as the early 1950s, Nelson has observed in vitro and in vivo experiments that the complex formed by the binding of microorganisms to their corresponding antibodies and complement can adhere to the erythrocytes of normal humans, monkeys, baboons and the like, thereby enhancing phagocytosis of leukocytes and This phenomenon of immunoadhesion is thought to be part of the host defense mechanism. In the 1960s and 1970s, the immune function of the lymphatic system has been further studied, but the immune function of erythrocytes has not been given enough attention. In 1981, Siegel et al. Proposed a new concept of erythrocyte immune function, assuming that erythrocytes are also one of the essential components of the immune system. However, its mechanism, regulatory factors, genetic and disease and other needs to be further explored. Here is a brief introduction to the existing materials.