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目的:为研究中药地锦草抗HBV活性物质基础。方法:采用聚酰胺、大孔树脂、Sephadex LH-20,MCI GEL CHP20P等色谱方法,从地锦草70%乙醇提取物中分离得到7个酚性化合物。结果:利用MS,NMR等波谱分析手段鉴定了化合物的结构,分别为:短叶苏木酚(brevifolin,1),短叶苏木酚酸(brevifolin carboxylic acid,2),短叶苏木酚酸甲酯(methyl brevifolin-carboxylate,3),phyllanthussin E methyl ester(4),地榆酸双内酯(sanguisorbic acid dilactone,5),3,3′-二甲氧基鞣花酸(3,3′-2-di-O-methyl ellagic acid,6),鞣花酸(ellagic acid,7)。结论:化合物2~6为首次从该植物中分得。
OBJECTIVE: To study the anti-HBV active substance basis of Chinese herbal medicine. Methods: Seven phenolic compounds were isolated from 70% ethanol extract of Aegiceras corniculatum by using polyamide, macroporous resin, Sephadex LH-20, MCI GEL CHP20P and other chromatographic methods. Results: The structures of the compounds were identified by spectral analysis of MS and NMR. They were brevifolin (1), brevifolin carboxylic acid (2), methyl brevifolin- carboxylate, 3), phyllanthussin E methyl ester (4), sanguisorbic acid dilactone (5), 3,3’-2-di-O -methyl ellagic acid, 6), ellagic acid (7). Conclusion: Compounds 2 ~ 6 were obtained from this plant for the first time.