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运用小鼠迟发型变态反应（ＤＴＨ）模型和组织胺（Ｈ）、５－羟色胺（５－ＨＴ）诱发大鼠皮肤炎症性渗出的方法，观察了左旋门冬氨酸钙（Ｌ－Ｃａ－Ａｓｐ）对小鼠耳肿胀和大鼠皮肤炎症反应的影响，并与葡萄糖酸钙（Ｃａ－Ｇｌｕ）作比较。结果表明，Ｌ－Ｃａ－Ａｓｐｉｐ１６５ｍｇ·ｋｇ－１和３３０ｍｇ·ｋｇ－１对小鼠ＤＴＨ有明显的抑制作用；Ｌ－Ｃａ－Ａｓｐｉｐ２５０ｍｇ·ｋｇ－１和５００ｍｇ·ｋｇ－１对Ｈ、５－ＨＴ分别诱导的大鼠皮肤炎症性渗出亦有较明显的抑制作用，其抑制效应不亚于Ｃａ－Ｇｌｕ，提示Ｌ－Ｃａ－Ａｓｐ对动物过敏和（或）炎症反应具有一定的抑制作用。
The effects of delayed-type hypersensitivity (DTH) and histamine (H) and serotonin (5-HT) -induced skin inflammatory exudation in mice were observed. The effects of L-Ca- Asp on mouse ear swelling and inflammatory reaction in rat skin and compared with calcium gluconate (Ca-Glu). The results showed that L-Ca-Aspip 165 mg · kg-1 and 330 mg · kg-1 had a significant inhibitory effect on DTH in mice; L-Ca-Aspip 250 mg · kg-1 and 500 mg · kg- Induced inflammatory exudation in rat skin also had obvious inhibitory effect, the inhibitory effect was as good as that of Ca-Glu, suggesting that L-Ca-Asp has certain inhibitory effect on animal allergy and / or inflammatory reaction.