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给吗啡依赖大鼠侧脑室注射环磷酸腺苷（ｃＡＭＰ）及其衍生物二丁酰环磷酸腺苷（ｄｂｃＡＭＰ），以提高大脑外源性ｃＡＭＰ，此时可加重大鼠吗啡戒断症状，并呈明显的剂量效应关系。侧脑室注射裂解ｃＡＭＰ的磷酸二酯酶（ＰＤＥ）抑制剂茶碱，以提高大脑内源性ｃＡＭＰ时，也可加重大鼠吗啡戒断症状。相反，侧脑室注射ＰＤＥ激动剂咪唑，使大脑内源性ｃＡＭＰ减少，则可使大鼠吗啡戒断症状减轻。上述结果可能有助于发展治疗吗啡戒断症状的新药。
Morphine-dependent rats were injected intracerebroventricular injection of cyclic adenosine monophosphate (cAMP) and its derivative of dibutyryl cyclic adenosine monophosphate (dbcAMP), in order to increase exogenous cAMP in the brain at this time can exacerbate the symptoms of morphine withdrawal in rats, and was significantly Dose-response relationship. Intracerebroventricular injection of cAMP phosphodiesterase (PDE) inhibitor theophylline, in order to improve brain endogenous cAMP, morphine withdrawal symptoms may also increase in rats. In contrast, intracerebroventricular injection of PDE agonist imidazole, so that the brain endogenous cAMP decreased, then morphine withdrawal symptoms can be alleviated in rats. The above results may help to develop new drugs for the treatment of morphine withdrawal symptoms.