雄性大白鼠24只,随机分成3组各8只。A组为对照组,在大脑中动脉凝闭(MCAO)前30min静注蒸馏水;B组在MCAO前30min静注尼莫地平0.6mg/kg;C组在MCAO后40min静注尼莫地平1mg/kg;用钙离子选择性微电极观察脑梗死区细胞外Ca~(2+)变化。结果:B组脑梗死区细胞外Ca~(2+)下降值较小,A组下降值较大(P<0.01);C组给药前后自身对照脑梗死区细胞外Ca~(2+)明显回升(P<0.01)。实验表明,在MCAO前或后给药,尼莫地平对脑梗死区细胞外Ca~(2+)流动均有阻滞作用。 24 male rats were randomly divided into 3 groups of 8 each. Group A was treated with distilled water 30 minutes before middle cerebral artery occlusion (MCAO); Group B with nimodipine 0.6 mg / kg 30 minutes before MCAO; Group C with nimodipine 1 mg / kg; Extracellular Ca ~ (2+) changes in cerebral infarction area were observed by calcium ion selective microelectrode. Results: The decrease of extracellular Ca2 + in cerebral infarction area of ​​group B was smaller than that in group A (P <0.01) Significantly increased (P <0.01). Experiments show that, before or after MCAO administration, nimodipine on cerebral infarction extracellular Ca ~ (2+) flow has a blocking effect.