论文部分内容阅读
侵袭转移是恶性肿瘤的基本特征和重要标志,也是导致肿瘤患者死亡的主要原因。上皮-间质转化(epithelial-mesenchymal transition,EMT)是肿瘤侵袭转移的首要步骤。研究表明,细胞融合是肿瘤发生转移过程中的常见现象之一。间充质干细胞(mesenchymal stem cell,MSC)是细胞融合中广泛涉及的一种重要细胞,并通过细胞融合在肿瘤发生转移过程中发挥重要作用。本文主要综述了间充质干细胞与肿瘤细胞融合在肿瘤转移中的最新研究进展,其机制的阐明有可能为肿瘤治疗提供新的策略。
Invasion and metastasis are the basic features of malignant tumors and an important symbol, but also lead to death of cancer patients the main reason. Epithelial-mesenchymal transition (EMT) is the first step in tumor invasion and metastasis. Studies have shown that cell fusion is one of the common phenomena in tumor metastasis. Mesenchymal stem cells (MSCs) are an important cell widely involved in cell fusion and play an important role in tumor metastasis through cell fusion. This review summarizes the recent progress in the study of mesenchymal stem cells and tumor cell fusion in tumor metastasis. The elucidation of the mechanism may provide a new strategy for tumor therapy.