支气管哮喘是以可逆性气道阻塞、支气管高反应性和气道炎症为特征的复杂的临床综合征。气道炎症的形成和扩展有多种因素参与,其中多种细胞产生的介质起着重要的作用。白三烯(LT)是细胞膜花生四烯酸氧化代谢所产生的具有生物活性的脂肪酸,是参与哮喘发病的最重要的前炎症介质之一。近年来许多研究者热衷于抗LT药物防治哮喘的研究,现综述于下。 Bronchial asthma is a complex clinical syndrome characterized by reversible airway obstruction, bronchial hyperresponsiveness and airway inflammation. There are many factors involved in the formation and expansion of airway inflammation, of which a variety of cell-derived mediators play an important role. Leukotrienes (LTs) are biologically active fatty acids produced by the oxidative metabolism of arachidonic acid in cell membranes and are one of the most important proinflammatory mediators involved in the pathogenesis of asthma. In recent years, many researchers are keen on the anti-LT drug anti-asthma research, are summarized below.