患者陈某,女,34岁,家属。平素身体健康,无药物过敏史,于1984年5月8日晚8时进行霍乱菌苗预防注射,左上臂三角肌外侧行常规消毒后,深层皮下注射吸附浓方霍乱菌苗0.5ml(系卫生部武汉生物制品研究所生产,同一支注射8人均无反应)。9时患者感全身微寒、头晕,随之入睡。大约10时,患者突然寒战,全身发抖,下床不能站立,同时感胸部发闷,呼吸紧迫感,并诉说心慌,剧烈头痛,恶心欲吐。查体温41.3℃,血压140/90,脉搏130次,呼吸每分38次,面色苍白,神志清楚,口唇微发绀,心肺(一),其他检查均属正常。诊断为霍乱菌苗严重过敏反应,立即肌肉注射非那根25mg,口服安定片 Patient Chen, female, 34 years old, relatives. Normally healthy, no drug allergy history, at 8 o’clock on the May 8, 1984 for cholera vaccine injection, the lateral left upper quadrant deltoid routine disinfection, deep subcutaneous injection of concentrated cholera vaccine 0.5ml (Department of Health Department of Wuhan Institute of Biological Products produced the same injection of 8 were no response). At 9:00, the patient felt slightly cold and dizzy, then fell asleep. About 10 o’clock, the patient suddenly chills, trembling, get out of bed can not stand, while feeling chest stuffiness, sense of urgency of breathing, and complain of palpitation, severe headache, nausea and vomiting. Check body temperature 41.3 ℃, blood pressure 140/90, pulse 130 times, breathing 38 points per minute, pale, conscious, micro-cyanotic lips, cardiopulmonary (A), the other tests are normal. Diagnosis of cholera vaccine serious allergic reactions, intramuscular injection of non-root 25mg, oral stability tablets