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目的观察甲氨蝶呤联合米非司酮治疗剖宫产术后瘢痕妊娠的治疗效果。方法将剖宫产术后瘢痕妊娠患者91例随机分为观察组46例和对照组45例,对照组给予甲氨蝶呤治疗,观察组在对照组治疗的基础上给予米非司酮,比较2组患者的治疗效果。结果观察组总有效率为95.65%高于对照组的75.56%,差异有统计学意义(P<0.05);2组治疗后血β-人绒毛膜促性腺激素(β-h CG)水平均降低,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后2组妊娠包块均减小(P<0.05),但组间比较差异无统计学意义(P>0.05)。结论甲氨蝶呤联合米非司酮治疗剖宫产术后瘢痕妊娠效果好,值得在临床上推广使用。
Objective To observe the effect of methotrexate and mifepristone on the treatment of scar pregnancy after cesarean section. Methods Ninety-one patients with scar pregnancy after cesarean section were randomly divided into observation group (n = 46) and control group (n = 45). The control group was treated with methotrexate. The observation group was given mifepristone on the basis of the control group 2 groups of patients treatment effect. Results The total effective rate in the observation group was 95.65%, which was significantly higher than that in the control group (75.56%, P <0.05). The levels of β-hCG decreased , And the observation group was lower than the control group, the differences were statistically significant (P <0.05); after treatment, the mass of two groups of pregnancy were reduced (P <0.05), but there was no significant difference between the two groups (P> 0.05 ). Conclusion Methotrexate combined with mifepristone treatment of cesarean scar pregnancy has good effect, it is worth to promote the use of the clinic.