The striping pattern nonuniformity of the infrared line scanner (IRLS) severely limits the system performance. An adaptive nonuniformity correction (NUC) algorithm for IRLS using neural network is proposed. It uses a one-dimensional median filter to generate ideal output of network and can complete NUC by a single frame with a high correction level. Applications to both simulated and real infrared images show that the algorithm can obtain a satisfactory result with low complexity, no need of scene diversity or global motion between consecutive frames. It has the potential to realize real-time hardware-based applications.