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目的了解女性小细胞肺癌的临床特征分布。方法收集2006年1月至2012年11月大连医科大学附属二院收治的341例小细胞肺癌女性患者88例的临床资料,分析患者在年龄、分期、就诊症状、体重下降、吸烟、家族史、肿瘤位置、治疗方式、疗效反应等方面的特征。结果 2006-2012年该院女性小细胞肺癌住院患者数呈上升趋势;女性患者平均患病年龄为(57.8±11.2)岁,小于同期男性患者(60.4±10.3)岁;女性<65岁患者比例高于男性患者(73.9%vs 67.5%),两者比较差异有统计学意义(P=0.018);女性患者吸烟只有13.6%,远远低于男性患者吸烟比例(85.5%),两者比较差异有统计学意义(P=0.000);女性家族史、体重下降、就诊症状、肿瘤位置、分期、疗效以及治疗方式的选择均与男性无差别。在广泛期小细胞肺癌中观察到女性最常见的远处转移是肝转移(40.0%),男性肝转移只占22.2%,两者比较差异有统计学意义(P=0.036)。结论女性小细胞肺癌数一直呈上升趋势;女性小细胞肺癌就诊的平均年龄小于男性患者;在中青年小细胞肺癌中女性常见;女性吸烟患者较少;相对于男性患者,女性更常见于肝转移。
Objective To understand the clinical characteristics of female small cell lung cancer. Methods The clinical data of 341 patients with small cell lung cancer admitted to the Second Affiliated Hospital of Dalian Medical University from January 2006 to November 2012 were collected. The clinical data of 88 patients with small cell lung cancer were collected and analyzed in terms of age, staging, symptom, weight loss, smoking, family history, Tumor location, treatment, response and other aspects of the characteristics. Results The number of hospitalized patients with small cell lung cancer in women increased from 2006 to 2012. The average age of female patients was (57.8 ± 11.2) years old, less than that of male patients (60.4 ± 10.3) years and female patients <65 years There was significant difference between male and female (73.9% vs 67.5%, P = 0.018). Female smoking was only 13.6%, far lower than that of male (85.5%), the difference was statistically significant Statistical significance (P = 0.000); Female family history, weight loss, treatment symptoms, tumor location, staging, efficacy and treatment options were indistinguishable from men. In extensive stage small cell lung cancer, the most common distant metastasis in women was observed in liver metastases (40.0%) and in men (22.2%), with significant differences between the two groups (P = 0.036). Conclusions The number of small cell lung cancer in women has been on an upward trend. The average age of women with small cell lung cancer is less than that of male patients. Female are common in young and middle-aged patients with small cell lung cancer. There are fewer female patients with smoking. Compared with male patients, women are more common in liver Transfer.