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目的 观察局部注射乙酸对裸鼠移植性肝癌的治疗作用 ,为临床应用此方法治疗肝癌提供实验依据 .方法 建立裸鼠移植性肝癌模型 ,观察治疗后肿瘤体积、光镜及电镜变化 .结果 在第 4次注射乙酸前 ,裸鼠移植瘤消失 ,疗效优于乙醇注射组 (P<0 .0 1) ,且无明显毒副作用 .结论 乙酸可用于肝癌的局部注射治疗 ,有较好的疗效
Objective To observe the therapeutic effect of local injection of acetic acid on transplanted hepatocellular carcinoma in nude mice and provide experimental basis for the clinical application of this method in the treatment of hepatocellular carcinoma.Methods Transplanted hepatocellular carcinoma model was established in nude mice and the changes of tumor volume, light microscope and electron microscope after treatment were observed. Before 4 injections of acetic acid, the xenograft tumor disappeared in the nude mice, which was superior to that of the ethanol injection group (P<0.01). There was no obvious toxic side effect. Conclusion Acetic acid can be used for the local injection treatment of liver cancer.