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【发病机理】自从观察到结节病的结核菌素皮试阴性以来,该病细胞免疫与体液免疫的一些异常已被公认。病人通常合并有T淋巴细胞减少,血液T细胞耗竭,后者与T细胞向活动性病变部位重新分布有关。根据血液中和炎症部位单克隆抗体所测出的T细胞亚群值,显示出活动性结节病病人OK T4~+辅助细胞的重新分布。对照组支气管肺泡灌洗(BAL)液中的OK T4/OK T8的比值与血中(1.8～1.0)所得的比值相吻合,而活动性结节病病人,其病变部位OK T4~+细胞显著增加;因此,BAL液中OK T4/OK T8
[Pathogenesis] Since the observed sarcoidosis of tuberculin skin test negative, the disease of cellular immunity and humoral immunity some have been recognized. Patients usually have a combination of T-lymphocyte depletion and depletion of T-cells in the blood, which is associated with redistribution of T cells to active lesion sites. T cell subsets, measured by monoclonal antibodies in the blood and at the site of inflammation, showed a redistribution of OK T4 ~ + helper cells in patients with active sarcoidosis. In the control group, the ratio of OK T4 / OK T8 in bronchoalveolar lavage fluid (BAL) was in good agreement with the ratio in blood (1.8-1.0), while in patients with active sarcoidosis, OK T4 ~ + cells were significantly Increase; therefore, OK T4 / OK T8 in BAL fluid