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目的比较厄贝沙坦,拉西地平和赖诺普利对42例高血压病患者的降压疗效。方法采用随机,单盲和交叉的方法 ,运用24h动态血压监测。结果 3类药均能显著降低血压,彼此间降低偶测血压的幅度无显著差异,经厄贝沙坦、拉西地平降低24h平均和白天平均血压的幅度大于赖诺普利。3类药均能有效控制清晨血压高峰期的血压。它们的降压谷峰值超过65%。结论厄贝沙坦,拉西地平和赖诺普利均可每日服用1次,前2类药控制24h血压及清晨醒后的高峰期血压较后者为佳。
Objective To compare the antihypertensive efficacy of irbesartan, lacidipine and lisinopril in 42 patients with essential hypertension. Methods Randomized, single-blind and crossover methods were used to monitor 24h ambulatory blood pressure. Results All the three drugs could significantly reduce the blood pressure and reduce the occasional blood pressure between the two groups. There was no significant difference between the two groups in the mean blood pressure and the average daytime blood pressure of irbesartan and lacidipine than lisinopril. 3 kinds of drugs can effectively control the blood pressure during early morning peak blood pressure. Their peak pressure drops over 65%. Conclusion Irbesartan, lacidipine and lisinopril can be taken once daily. The former two kinds of drugs control the blood pressure of 24h and the peak blood pressure after waking up early is better than the latter.