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目的通过分析极低出生体重儿不同程度纤维蛋白原颅内出血、消化道出血、肺出血发生率,探讨极低出生体重儿应用冷沉淀指征。方法选择347例极低出生体重儿,按纤维蛋白原分为:<0.8g/L组、0.8g/L~组、≥1.2g/L三组,比较其颅内出血、消化道出血、肺出血的发生率。结果研究对象颅内出血、消化道出血、肺出血的发生率分别为16.7%,9.51%,4.03%,三组之间颅内出血、消化道出血、肺出血的发生率差异有统计学意义(P<0.05)。结论纤维蛋白原越低颅内出血、消化道出血、肺出血的发生率越高;对纤维蛋白原浓度低于1.2g/L的低出生体重儿应考虑输注冷沉淀,在改善早产儿预后及提高成活率方面具有积极的临床意义。
Objective To analyze the incidence of intracranial hemorrhage, gastrointestinal bleeding and pulmonary hemorrhage in patients with very low birth weight and different degrees of fibrinogen, and to investigate the application of cryoprecipitation in very low birth weight children. Methods 347 cases of very low birth weight infants were divided into three groups according to fibrinogen: <0.8g / L group, 0.8g / L ~ group, ≥1.2g / L, and compared their intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage The incidence of. Results The incidences of intracranial hemorrhage, gastrointestinal bleeding and pulmonary hemorrhage were 16.7%, 9.51%, 4.03% respectively. There was significant difference in the incidence of intracranial hemorrhage, gastrointestinal bleeding and pulmonary hemorrhage between the three groups (P < 0.05). Conclusions The lower the incidence of intracranial hemorrhage, gastrointestinal bleeding and pulmonary hemorrhage, the lower the fibrinogen. The infusion of cryoprecipitate should be considered for low birth weight infants with fibrinogen concentration less than 1.2g / L. Improve the survival rate has a positive clinical significance.