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本文报道了ＨＩＶ蛋白酶抑制剂替普那韦（ｔｉｐｒａｎａｖｉｒ，ＰＮＵ－１４０６９０）的一条新合成路线，合成的替普那韦为白色固体，熔点为８６～８９℃。 替普那韦的Ⅰ／Ⅱ期临床试验在ＨＩＶ病毒阳性、未接受过蛋白酶抑制剂治疗的２４名病人身上通过多剂量给药方案进
This article reports a new synthetic route for the HIV protease inhibitor tipranavir (PNU-140690), which is a white solid that has a melting point of 86-89 ° C. Phase I / II clinical trials of tepnavir were performed in multiple doses of 24 HIV-positive, untreated patients with protease inhibitors