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对方证相应寒热证动物模型研究进展的文献进行整理和分析。以寒热证动物模型、方证相应为关键词,检索了近20年中国知识资源总库,得到相关文献229篇,逐篇阅读、甄别、梳理和选择。采纳参考文献19篇。以方致证的寒热证动物模型,有采用温热方剂制作热证动物模型,也有采用寒凉方剂制作寒证动物模型。其他方法致寒热动物模型及以方治证,有采用灌服冰水、干辣椒粉等方法致脾胃寒热证动物模型,并治以理中丸、大黄黄连泻心汤等温热、寒凉方剂,也有肠热证动物模型治以大承气汤,湿热证动物模型治以加味四妙散等。寒热证动物模型及方证相应的报道虽多,但有待上升到较统一的认识;建立准确的寒热证动物模型,进行方证相应的研究,须找到可供观察的特异性客观指标;在观察和评价寒热证的时候,要重视体质因素;可尝试用寒热偏性的方剂制作寒证热证动物模型,然后选用寒热偏性的方剂进行治疗。
Corresponding evidence of cold and heat syndrome animal model research literature review and analysis. Taking the cold and heat syndrome animal model and the corresponding syndrome as the key words, we retrieved the general database of China’s knowledge resources for nearly 20 years and obtained 229 articles, reading, screening, combing and selecting. Adopted 19 references. In order to prove the card type of animal models of cold and heat syndrome, there is the use of warming prescription heat animal model, but also the use of cold prescription cold animal model. Other methods of animal models of cold and heat and to cure syndrome, there is irrigation with ice water, dried paprika and other methods of animal model of the spleen and stomach cold and heat syndrome, and rule to the pill, rhubarb Huangxie Xie Tang and other warm, cold prescription, There are intestine heat syndrome animal model governance Dachengqi Tang, damp-heat syndrome animal model to cure four Miaosan and so on. Cold and heat syndrome animal model and the corresponding number of reports, although there are many, but to be raised to a more uniform understanding of the establishment of an accurate model of cold and heat animal model for the corresponding study, we must find a specific objective indicators for observation; observed And evaluation of cold and heat syndrome, we must pay attention to physical factors; try cold and heat prescriptions cold syndrome animal models, and then use the cold partial heat prescription for treatment.