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[目的]探讨中介素(IMD)对脓毒症患者病情严重程度以及生存状况的影响.[方法]94 例脓毒症患者为观察组,8 6 例体检健康者为对照组.根据患者脓毒症病情的严重程度将观察组患者分为全身炎症反应综合征(SIRS)组 1 8 例、脓毒症组 34 例、严重脓毒症组 22 例以及脓毒症休克组 20 例.比较观察组与对照组患者 IMD、血清脂联素、肿瘤坏死因子-α(TNF-α)以及C反应蛋白(CRP)含量水平;比较四组脓毒症患者急性生理学与慢性健康状况评分系统Ⅱ评分(APACHEⅡ)以及序贯器官衰竭估计评分(SOFA).[结果]观察组患者 IMD 与血清脂联素水平均低于、TNF-α与CRP水平均高于对照组(P <0.05).SIRS组、脓毒症组、严重脓毒症组以及脓毒症休克组 IMD与血清脂联素水平依次递减、TNF-α与CRP水平和 APACHEⅡ,SOFA评分以次递增,四组数据比较差异均有显著性(P <0.05).[结论]IMD在脓毒症患者中呈现较低水平,且患者病情越严重 IMD 水平越低,临床可通过其对脓毒症患者病情进行预估.“,”[Objective]To investigate the effect of Intermedin (IMD)on the severity and survival of sepsis pa-tients.[Methods]Ninety-four cases of sepsis were observed group,86 cases of healthy people were control group. According to the severity of sepsis,the patients in the observation group were divided into 1 8 cases of systemic in-flammatory response syndrome (SIRS),34 cases of sepsis,22 cases of severe sepsis and 20 cases of septic shock. The levels of IMD,serum adiponectin,tumor necrosis factor-alpha (TNF-alpha)and C-reactive protein (CRP) were compared between the observation group and the control group.The acute physiology and chronic health score Ⅱ (APACHE Ⅱ)and the sequential organ failure assessment score (SOFA)were compared between the four groups.[Results]The levels of IMD and serum adiponectin in the observation group were lower than those in the control group,and the levels of TNF-alpha and CRP were higher than those in the control group (P<0.05). The levels of IMD and serum adiponectin in the SIRS group,sepsis group,severe sepsis group and the septic shock group decreased in turn,the levels of TNF-alpha and CRP,APACHE Ⅱ and SOFA scores increased in turn,with significant differences among the four groups (P<0.05).[Conclusion]IMD is lower in sepsis patients, and the more serious the condition is,the lower the level of IMD is.The clinical condition of sepsis patients can be predicted by IMD.