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本文研究了含高缓冲剂和低缓冲剂的乙酰水杨酸(ASA)片剂的体外溶解、缓冲作用及体内吸收、胃内缓冲作用和引起胃肠出血的原因。试验所用的样品:含低缓冲剂的ASA片剂(Ⅰ)(每片含ASA500mg、氧化镁70mg);含高缓冲剂ASA片剂(Ⅱ)(每片含ASA325mg、碳酸氢钠525mg、碳酸钠75mg)。体外研究溶出速率:取片剂1片置于金属网篮中,将篮放入盛有无酶人工胃液(37℃)500ml的改进Levy烧杯中,搅拌速度40rpm,于1、2、3、5分钟取样,过滤,测定含量。分别测定5片。结果表明,I的溶出速率显著地低
In this paper, we investigated the in vitro dissolution, buffering and in vivo absorption of acetylsalicylic acid (ASA) tablets with high and low buffering agents, the intragastric buffering and the causes of gastrointestinal bleeding. ASA tablets with low buffer (I) (500 mg each ASA, 70 mg magnesium oxide); ASA tablets (II) with high buffer (each ASA 325 mg, sodium bicarbonate 525 mg, sodium carbonate 75mg). In vitro dissolution rate: Take a tablet placed in a metal basket, the basket into the enzyme-free artificial gastric juice (37 ℃) 500ml improved Levy beaker, stirring speed 40rpm, at 1,2,3,5 Minute sampling, filtration, determination of content. Five were measured. The results show that the dissolution rate of I is significantly lower