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为探讨血清前白蛋白（ＰＡＢ）和总胆汁酸（ＴＢＡ）在慢性肝病中的临床价值，分别检测慢性乙肝（轻度、中度、重度）、肝硬化（代偿期和失代偿期）患者及正常对照组的血清ＰＡＢ、ＴＢＡ及白蛋白（Ａ）、总胆红素（ＴＢＩＬ）水平，并进行分析。结果显示，各型慢性肝病患者血清ＰＡＢ均显著低于对照组（Ｐ＜０．０５或Ｐ＜０．０１），而血清ＴＢＡ则明显高于对照组（Ｐ＜０．０５或Ｐ＜０．０１）。轻、中度慢性乙型肝炎患者的血清ＰＡＢ、ＴＢＡ异常率均高于同组Ａ和ＴＢＩＬ的异常率（Ｐ＜０．０５）。提示联合检测血清ＰＡＢ和ＴＢＡ有助于发现肝脏合成及代谢功能的早期损害。
To investigate the clinical value of serum prealbumin (PAB) and total bile acid (TBA) in chronic liver disease, chronic hepatitis B (mild, moderate, severe), cirrhosis (decompensated and decompensated) Patients and normal control group serum PAB, TBA and albumin (A), total bilirubin (TBIL) levels, and analyzed. The results showed that serum PAB in patients with various types of chronic liver disease was significantly lower than that in the control group (P <0.05 or P <0.01), while serum TBA was significantly higher than that in the control group (P <0.05 or P <0. 01). The abnormal rates of serum PAB and TBA in mild and moderate chronic hepatitis B patients were higher than those in the same group A and TBIL (P <0.05). It is suggested that the combined detection of serum PAB and TBA can help detect the early damage of liver synthesis and metabolism.